发明名称 |
COMPOSITIONS AND METHODS FOR IMMUNOSTIMULATORY RNA OLIGONUCLEOTIDES |
摘要 |
The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.
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申请公布号 |
US2009111765(A1) |
申请公布日期 |
2009.04.30 |
申请号 |
US20060066906 |
申请日期 |
2006.09.14 |
申请人 |
HARTMANN GUNTHER;HORNUNG VEIT |
发明人 |
HARTMANN GUNTHER;HORNUNG VEIT |
分类号 |
A61K31/7105;A61P3/00;A61P17/00;A61P25/00;A61P27/02;A61P31/00;A61P35/00;A61P37/00;C07H21/02;C12N15/117;C12P21/00;C12Q1/68 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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