METHODS AND COMPOSITIONS FOR TARGETING FENESTRATED VASCULATURE
摘要
Targeting of a fenestrated vasculature at a body site by micro or nanoparticles can be increased by using particles that have a radius substantially equal to a critical radius of a normal vasculature at the body site. The particles can be used for treating or monitoring a physiological condition responsible for the fenestrated vasculature. A method of improving an ability of micro or nanoparticles to target fenestrated blood vessels in a body site by selecting particles from a population of the micro or nanoparticles, where the selected particles have a radius that permits enhanced delivery into the fenestrated blood vessels.
申请公布号
WO2008041970(A3)
申请公布日期
2009.04.30
申请号
WO2006US38196
申请日期
2006.09.28
申请人
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION;DECUZZI, PAOLO;FERRARI, MAURO