METHODS, SYSTEMS, AND COMPUTER PROGRAM PRODUCTS FOR OPTIMIZATION OF PROBES FOR SPECTROSCOPIC MEASUREMENT IN TURBID MEDIA

摘要

The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. A probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an Inversion algorithm to produce corresponding optical properties as output and are compared to reference values. The simulation and inversion steps are repeated and compared for a plurality of additional probe geometries and an optimal geometry is selected.