ISOINDOLONES WITH HIGH BINDING AFFINITY TO beta;-AMYLOID AGGREGATES AND FIBRILS, AND PREPARATION METHOD THEREOF

摘要

An Isoindolone compound showing excellent binding affinity to beta-Amyloid fibril is provided to treat and prevent degenerative brain diseases by inhibiting generation of beta-Amyloid fibril. A pharmaceutical composition comprises an Isoindolone compound represented by the formula 1 or pharmaceutically allowable salts. In the formula 1, A is C=O or CH2; R1 is a halogen atom selected among H, OH, F, Br and I, a substituted C1-C8 alkoxy group or a C1-C8 alkylamino group, of which the substituted group is selected among a C1-C8 alkyl group, a C1-C8 alkoxy group, a tosyloxy-C1-C8 alkoxy group, a mesyloxy-C1-C8 alkoxy group, a nosyloxy-C1-C8 alkoxy group, H, OH, F, Br and I; R2 is a C1-C8 alkyl group or a halogen atom selected among H, OH, F, Br and I; and R3 and R4 are independently H, a C1-C8 alkoxy group or a C1-C8 alkylamino group.