发明名称 |
Isolated polynucleotides having a reduced or an increased content of epigenetic control motifs and uses thereof |
摘要 |
The present invention is concerned with modified polynucleotides derived from a native gene and having a reduced or increased number of epigenetic control motifs, at the nucleotide level, as compared to the native gene. These polynucleotides are useful to study, increase and/or reduce genes expression, and to improve DNA vaccination methods. The present invention also relates to methods of using these modified polynucleotides in in vitro and in vivo expression systems.
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申请公布号 |
EP2053127(A2) |
申请公布日期 |
2009.04.29 |
申请号 |
EP20080004452 |
申请日期 |
2000.12.06 |
申请人 |
INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
NICOLAS, JEAN-FRANCOIS;HENRY, ISABELLE;CHOULIKA, ANDRE |
分类号 |
C12N15/09;C12N15/67;A01K67/027;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/38;C12N15/56;C12N15/63;C12Q1/34 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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