发明名称 |
Process for the preparation of a hydrate of an anthranilic acid derivative |
摘要 |
A hydrate of an acid addition bis-salt of an anthranilic acid derivative is produced by a process which comprises: (a) combining, in any order, the anthranalic acid derivative, a pharmaceutically acceptable organic solvent, an excess of water and a pharmaceutically acceptable strong acid to form a mixture; (b) warming the mixture until a clear solution forms; (c) filtering the solution while it is warm, to yield a filtrate; and (d) recovering the hydrate as defined above from the filtrate. The hydrate has a defined number of moles of water of crystallization and possesses better storage stability and dissolution characteristics than conventionally produced hydrates of such acid addition bis-salts.
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申请公布号 |
US7524861(B2) |
申请公布日期 |
2009.04.28 |
申请号 |
US20050513986 |
申请日期 |
2005.04.08 |
申请人 |
HAYMAN DAVID FRANK;WRIGHT MICHAEL |
发明人 |
HAYMAN DAVID FRANK;WRIGHT MICHAEL |
分类号 |
C07D215/54;C07D401/12;A61K31/47;A61K31/4709;A61K31/4725;A61K31/4738;A61K31/497;A61K31/4985;A61P31/00;A61P35/00;A61P43/00;C07D217/04;C07D217/26;C07D401/14;C07D405/04;C07D405/14;C07D409/14;C07D491/056;C07D495/04 |
主分类号 |
C07D215/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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