| 发明名称 |
Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation |
| 摘要 |
The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.
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| 申请公布号 |
US7524495(B2) |
申请公布日期 |
2009.04.28 |
| 申请号 |
US20050546160 |
申请日期 |
2005.08.22 |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
ULLRICH AXEL;GSCHWIND ANDREAS;HART STEFAN |
| 分类号 |
A61K39/395;A61K38/00;A61K39/00;C07K14/485;C12N9/64;G01N33/53 |
主分类号 |
A61K39/395 |
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