ACYCLIC AMINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE
摘要
The present invention relates to compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
申请公布号
EP2049543(A1)
申请公布日期
2009.04.22
申请号
EP20070834862
申请日期
2007.09.07
申请人
INDUSTRIAL RESEARCH LIMITED;ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人
CLINCH, KEITH;EVANS, GARY BRIAN;FROEHLICH, RICHARD;FURNEAUX, RICHARD HUBERT;KELLY, PETER MICHAEL;MASON, JENNIFER MARY;SCHRAMM, VERN L.;TYLER, PETER CHARLES