SPARC-DERIVED CANCER REJECTION ANTIGEN PEPTIDE AND PHARMACEUTICAL COMPRISING THE SAME

摘要

The object is to identify a peptide derived from SPARC protein which can induce a human cytotoxic (killer) T cell and a helper T cell both reactive to a tumor, and to provide a means for enabling a tumor immunotherapy in a cancer patient having a high level of SPARC expression. Disclosed is a peptide (A) or (B): (A) a peptide which comprises an amino acid sequence depicted in any one of SEQ ID NOs:1-3; and (B) a peptide which comprises an amino acid sequence having the substitution or addition of one or several amino acid residues in a peptide comprising an amino acid sequence depicted in any one of SEQ ID NOs:1-3 and which can induce a killer T cell.