New cyclic peptides having a random alternation of L-alpha-aminoacyl residues and aza-beta-3-aminoacyl residues, useful to treat infectious diseases e.g. nosocomial infections, tuberculosis and septicemia

摘要

Cyclic peptides having a random alternation of L-alpha -aminoacyl residues and aza-beta 3>-aminoacyl residues (A), are new. Cyclic peptides having a random alternation of L-alpha -aminoacyl residues and aza-beta 3>-aminoacyl residues of formula (-NH-N(R 1)-CH 2-C(=O)-) (A), are new. R 1lateral chain comprising proteogenic or non-proteogenic group. Provided that, two L-alpha -aminoacyl residues are separated by at least one aza-beta 3>-aminoacyl residues and total number of L-alpha -aminoacyl residues and aza-beta 3>-aminoacyl residues is 4-8. ACTIVITY : Antimicrobial; Antibacterial; Antiparasitic; Virucide; Fungicide; Antitubercular; Tuberculostatic; Immunosuppressive; Antiinflammatory; Respiratory-Gen. MECHANISM OF ACTION : None given.