发明名称 |
COMBINATION THERAPY WITH GLATIRAMER ACETATE AND RILUZOLE |
摘要 |
The subject invention provides a method of providing neuroprotection to the central or peripheral nervous system of a subject in need of such neuroprotection comprising periodically administering to the subject an amount of glatiramer acetate and an amount of 2-amino-6-trifluoromethoxybenzathiazole, wherein the amounts when taken together are effective to provide neuroprotection to the central or peripheral nervous system of the subject. The subject invention also provides a package comprising glatiramer acetate, 2-amino-6-trifluorormethoxybenzothiazole and instructions for use together to provide neuroprotection to the central or peripheral nervous system of a subject in need of such neuroprotection. Additionally, the subject invention provides a pharmaceutical composition comprising an amount of glatiramer acetate and an amount of 2-amino-6-trifluorormethoxybenzothiazole, wherein the amounts when taken together are effective to provide neuroprotection to the central or peripheral nervous system of the subject. The subject invention further provides a pharmaceutical combination comprising separate dosage forms of an amount of glatiramer acetate and an amount of 2-amino-6-trifluorormethoxybenzothiazole, which combination is useful to provide neuroprotection to the central or peripheral nervous system of the subject. In addition, the combination therapy may be used to treat a subject afflicted with multiple sclerosis or one afflicted with amyotrophic lateral sclerosis. |
申请公布号 |
EP1778286(A4) |
申请公布日期 |
2009.04.08 |
申请号 |
EP20050724586 |
申请日期 |
2005.03.03 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
HAYARDENY, LIAT;KLINGER, ETY;BLAUGRUND, ERAN |
分类号 |
A61K31/785;A61K31/428;A61P25/00;A61P37/02 |
主分类号 |
A61K31/785 |
代理机构 |
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代理人 |
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地址 |
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