发明名称 |
COMPOSITIONS AND METHODS FOR INDUCING GENE EXPRESSION |
摘要 |
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivor proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.
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申请公布号 |
CA2311643(C) |
申请公布日期 |
2009.04.07 |
申请号 |
CA19982311643 |
申请日期 |
1998.12.04 |
申请人 |
GENZYME CORPORATION |
发明人 |
VINCENT, KAREN;GREGORY, RICHARD J. |
分类号 |
C12N15/09;C12N15/62;A61K31/7088;A61K31/711;A61K35/76;A61K38/00;A61K38/17;A61K48/00;A61P9/10;C07K14/47;C07K14/52;C07K19/00;C12N5/10;C12N15/12;C12N15/63;C12N15/86;C12Q1/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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