发明名称 |
Methods for inhibiting deacetylase activity |
摘要 |
A method for identifying a compound that inhibits the NAD+-dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the promotion of apoptosis in cancerous cells, and through the inhibition of transcriptional repressor activity in oncogenes.
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申请公布号 |
US7514406(B2) |
申请公布日期 |
2009.04.07 |
申请号 |
US20040496031 |
申请日期 |
2004.05.18 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
BEDALOV ANTONIO;GOTTSCHLING DANIEL E.;SIMON JULIAN |
分类号 |
A61K38/00;A61K31/352;A61K31/50;A61K31/513;C12Q1/26;C12Q1/44;G01N33/574 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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