| 摘要 |
A novel peptide-free compound is provided to inhibit beta-secretase, offer superior inhibiting activity a peptide-free compound and to offer superior cerebrum permeability of the compound through oral medication. A novel peptide-free compound for inhibiting beta-secretase includes a compound indicated as a chemical formula I, and salt or an isomer. In the formula 1, Y is N or C; R1 and R2 are independently hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycle, heteroaryl, aryl, - (CH2) m- aryl, - (CH2) m- heteroaryl, - C (O) - aryl or - C (O) - aryl- acyl; R3 and R5 are independently the hydrogen, the alkyl, the cycloalkyl, the heterocycle, the aryl or - (CH2) m- aryl; and R5 and R6 are independently the hydrogen, the alkyl, the cycloalkyl, the heterocycle, the aryl, the heteroaryl, - C (O) - alkyl, - C (O) - aryl, - C (O) - (CH2) m- aryl or - (CH2) m- aryl. The composition is used for curing Alzheimer disease.
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