发明名称 |
Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent |
摘要 |
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds-Free-B-ring flavonoids and flavans-for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
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申请公布号 |
US7514469(B2) |
申请公布日期 |
2009.04.07 |
申请号 |
US20030427746 |
申请日期 |
2003.04.30 |
申请人 |
UNIGEN PHARMACEUTICALS, INC. |
发明人 |
JIA QI |
分类号 |
A61K31/35;A61K31/353;A01N31/08;A01N43/04;A61K31/05;A61K31/352;A61K31/59;A61K31/69;A61K31/695;A61K31/70;A61K31/7048;A61K35/34;A61K36/00;A61K36/18;A61K36/47;A61P3/04;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P25/00;A61P25/04;A61P25/06;A61P25/28;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/02;A61P43/00 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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地址 |
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