| 发明名称 |
THF-CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE |
| 摘要 |
The present invention relates to a class of THF-containing sulfonamides whic h are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activit y and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.
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| 申请公布号 |
CA2217737(C) |
申请公布日期 |
2009.04.07 |
| 申请号 |
CA19962217737 |
申请日期 |
1996.04.18 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
TUNG, ROGER D. |
| 分类号 |
C07D307/14;C07D307/18;A61K31/33;A61K31/335;A61K31/34;A61K31/341;A61K31/343;A61K31/36;A61K31/38;A61K31/381;A61K31/40;A61K31/4025;A61K31/41;A61K31/4155;A61K31/42;A61K31/422;A61K31/425;A61K31/427;A61K31/44;A61K31/4427;A61K31/443;A61K31/4433;A61K31/445;A61K31/535;A61K38/00;A61P31/12;A61P31/18;A61P43/00;C07D207/26;C07D209/08;C07D213/30;C07D215/48;C07D231/14;C07D239/22;C07D263/24;C07D271/08;C07D277/36;C07D307/12;C07D307/20;C07D307/52;C07D307/64;C07D307/79;C07D403/12;C07D405/12;C07D405/14;C07D407/00;C07D407/12;C07D409/00;C07D409/12;C07D409/14;C07D411/00;C07D413/00;C07D413/12;C07D413/14;C07D417/00;C07D417/12;C07D493/04;C07D521/00;C07K5/078 |
主分类号 |
C07D307/14 |
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