发明名称 PIERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
摘要 The present invention discloses novel compounds of Formula I: having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11beta-HSD type 1 activity.
申请公布号 US2009088430(A1) 申请公布日期 2009.04.02
申请号 US20070297951 申请日期 2007.04.27
申请人 WALLACE OWEN BRENDAN;XU YANPING;YORK JEREMY SCHULENBURG 发明人 WALLACE OWEN BRENDAN;XU YANPING;YORK JEREMY SCHULENBURG
分类号 A61K31/454;A61K31/4545;A61K31/496;A61K31/5377;A61P3/10;C07D401/04;C07D401/14;C07D413/14 主分类号 A61K31/454
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