MICRO-SCALE RESONANT DEVICES AND METHODS OF USE

摘要

The invention relates to micro-resonant devices (MRDs in Figs. 2 or 8) that generate resonance at radio frequencies not present in an animal or human body, or present at low, background levels in the body. These individual, often monolithic devices, can be located in three- dimension space and tracked anywhere in a target area, e.g., in a human or animal body, or within a cell within a body, using a conventional magnetic resonance imaging (MRI) scanner or other transducers, e.g.. radiofrequency transducers. The MRDs generate high sensitively contrast in conventional clinical MRI scanners, have a diameter of anywhere from a few nanometers to 1000 microns, and can in some embodiments be manufactured using Micro-Electro-Mechanical System (MEMS) technology. The devices are optionally coated to isolate them from the environment, and this coating can be biocompatible coating for medical and biotechnology uses