| 发明名称 |
Heterocyclic Dye Compounds For In Vivo Imaging And Diagnosis Of Alzheimer's Disease |
| 摘要 |
The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as exemplified by compounds of the formula (1) in which Y is independently S, O, or N and m is 1, 2, or 3.
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| 申请公布号 |
US2009087376(A1) |
申请公布日期 |
2009.04.02 |
| 申请号 |
US20050632328 |
申请日期 |
2005.07.15 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;UNIVERSITY OF PITTSBURG OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
BACSKAI BRIAN;HYMAN BRADLEY T.;KLUNK WILLIAM E.;MATHIS CHESTER A.;SWAGER TIMOTHY;NESTEROV EVGUENI;HILLS IVORY |
| 分类号 |
A61K51/04;A61K49/00;A61K49/06;A61P25/00;C07D209/04;C07D249/04;C07D263/54;C07D277/62;C07D333/50;C07D403/02;C07D409/02 |
主分类号 |
A61K51/04 |
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