T CELL SUBPOPULATIONS CAPABLE OF TREATING CANCER

摘要

A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating lymphocytes (TILs) having a CD8+CD28-CD152- signature in a sample of the subject, wherein a frequency of TILs having the CD8+CD28-CD152- signature above a predetermined level is indicative of a positive responsiveness to cancer treatment. Other signatures reflecting responsiveness to cancer treatment are also disclosed. In addition, methods of treating cancer based on these signatures are also disclosed.