A high pressure liquid chromatography (HPLC) capillary device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column (160); at least one inlet connection (202) to the capillary column (160) for a sample fluid; and at least one outlet connection from the capillary column (160) for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube (360) for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column (160) through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column (160) for the sample fluid through a gas supply line with the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.
