| 摘要 |
<p>The present invention relates to a modified esterase with enhanced deacetylation activity for 7-ACA or its acyl amino derivative and cephalosporin C for the production of HACA and 3-deacetyl cephalosporin C, respectively, which carries one or more amino acid modification at residue positions when compared with the wild type esterase (MTCC 121) from the following group of residues, Aspartic acid at position 43, Methionine at position 138, Tyrosine at position 222 and Arginine at position 231.</p> |
| 申请人 |
ORCHID CHEMICALS & PHARMACEUTICALS LIMITED;DURAIRAAJ, MICHEAL;VINAYAGAM, VASU;MASILAMANI, TWINKLE, JASMINE;THIRUMOORTHY, RAMANAN;KRISHNAN, CAVERY, MANIAN;HARIT, RAVI, KANTH |
发明人 |
DURAIRAAJ, MICHEAL;VINAYAGAM, VASU;MASILAMANI, TWINKLE, JASMINE;THIRUMOORTHY, RAMANAN;KRISHNAN, CAVERY, MANIAN;HARIT, RAVI, KANTH |
