| 发明名称 |
QUINOLONE DERIVATIVE |
| 摘要 |
An extensive and intensive study was made on an NAD(P)H oxidase inhibitor. As a result, it was confirmed that a quinolone derivative having, at position-2, an alkyl group substituted by a hetero atom or the like had a good NAD(P)H oxidase inhibition activity. The compound has an inhibitory activity on the production of an active oxygen species, which relies on its NAD(P)H oxidase inhibition activity. Therefore, the compound can be used as a prophylactic and/or therapeutic agent for diabetes, impaired glucose tolerance, hyperlipemia, fatty liver, a diabetic complication and the like.
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| 申请公布号 |
CA2700088(A1) |
申请公布日期 |
2009.04.02 |
| 申请号 |
CA20082700088 |
申请日期 |
2008.09.25 |
| 申请人 |
ASTELLAS PHARMA INC. |
发明人 |
ONDA, KENICHI;IMAMURA, KENICHIRO;SATO, FUMIE;MORITOMO, HIROYUKI;URANO, YASUHARU;SAWADA, YUKI;ISHIBASHI, NAOKI;NAKANISHI, KEITA;YOKOYAMA, KAZUHIRO;FURUKAWA, SHIGETADA;MOMOSE, KAZUHIRO |
| 分类号 |
C07D215/22;A61K31/47;A61K31/4709;A61K31/496;A61K31/506;A61K31/5377;A61P1/16;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P9/12;A61P13/12;A61P19/02;A61P25/00;A61P25/28;A61P27/02;A61P29/00;A61P35/00;A61P39/06;A61P43/00;C07D401/12;C07D405/12;C07D405/14;C07D409/12;C07D491/107 |
主分类号 |
C07D215/22 |
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