An isolated polynucleotide encoding human kallikrein 1, a method for producing the encoded kallikrein 1, a vector comprising the polynucleotide and a host cell comprising the vector or a host cell into which the polynucleotide is integrated are disclosed. The polynucleotide can highly express in the host cell. The purity of the human kallikrein 1 after purification is at least 98%.
