发明名称 |
METHOD FOR PRODUCING HYDROXYLATED ADAMANTANE USING CYTOCHROME P450 |
摘要 |
<p>Disclosed is a method for producing a hydroxylated form of a compound having an adamantane skeleton, which is useful as an intermediate for functional resins and pharmaceutical products, with high yield and at low cost. Specifically, a hydroxylated form of a compound having an adamantane skeleton can be obtained by using cytochrome P450. More specifically, an N-(5-hydroxy-2-adamantyl)-benzamide derivative can be produced by hydroxylating an N-(2-adamantyl)-benzamide derivative.</p> |
申请公布号 |
WO2009041470(A1) |
申请公布日期 |
2009.04.02 |
申请号 |
WO2008JP67248 |
申请日期 |
2008.09.25 |
申请人 |
SHIONOGI & CO., LTD.;TOMIKAWA, TAIJIRO;MITSUDA, YUUICHI |
发明人 |
TOMIKAWA, TAIJIRO;MITSUDA, YUUICHI |
分类号 |
C12N15/53;C07C213/02;C07C233/65;C07D231/20;C12N9/06;C12P13/02 |
主分类号 |
C12N15/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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