The present invention is directed to alphavirus vectored vaccine contructs encoding paramyxovirus proteins that find use in the prevention of respiratory syncytial virus or human metapneumo virus infections. In particular, these vaccines induce cellular and humoral immune responses that inhibit RSV. Also disclosed are improved methods for producing alphavirus vectored paramyxovirus vaccines.
申请公布号
WO2009042794(A2)
申请公布日期
2009.04.02
申请号
WO2008US77721
申请日期
2008.09.25
申请人
VANDERBILT UNIVERSITY;CROWE, JAMES, E., JR.;MOK, HOYIN;JOHNSTON, ROBERT, E.;WILLIAMS, JOHN, V.;DAVIS, NANCY, L.
发明人
CROWE, JAMES, E., JR.;MOK, HOYIN;JOHNSTON, ROBERT, E.;WILLIAMS, JOHN, V.;DAVIS, NANCY, L.