摘要 |
The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2/3-d]pyrimidin-7- yl}cyclopentyl)methyl sulfamates, which are El activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with El activity. |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;ARMITAGE, IAN;ELLIOT, ERIC, L.;LANGSTON, MARIANNE;LANGSTON, STEVEN, P.;MCCUBBIN, QUENTIN, J.;MIZUTANI, HIROTAKE;STIRLING, MATTHEW;ZHU, LEI |
发明人 |
ARMITAGE, IAN;ELLIOT, ERIC, L.;LANGSTON, MARIANNE;LANGSTON, STEVEN, P.;MCCUBBIN, QUENTIN, J.;MIZUTANI, HIROTAKE;STIRLING, MATTHEW;ZHU, LEI |