摘要 |
<p>Small airway deposition of orientable drug particles in the lung due to interception is increased through alignment of these particles with an externally applied force such as a magnetic field. Drug particles in one embodiment are made magnetically responsive by loading them with magnetic nanoparticles. Elongated particles have a natural tendency to align parallel to the direction of flow through an airway, and therefore also parallel to airway walls; accordingly, alignment with a magnetic field to any other orientation increases interception, with a maximum increase for alignment perpendicular to airway walls. By positioning a magnetic field across a specific site within the lung, for example in the area of a tumor, the increase in deposition by interception allows localized targeting of inhaled drug particles to that area.</p> |
申请人 |
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA;FINLAY, WARREN, H.;MARTIN, ANDREW, ROBERT;ORSZANSKA, HELENA;THOMPSON, RICHARD |
发明人 |
FINLAY, WARREN, H.;MARTIN, ANDREW, ROBERT;ORSZANSKA, HELENA;THOMPSON, RICHARD |