发明名称 |
PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS |
摘要 |
<p>The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N-(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4' are each independently H or alkyl; or R4 and R4' together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.</p> |
申请公布号 |
CA2700979(A1) |
申请公布日期 |
2009.04.02 |
申请号 |
CA20082700979 |
申请日期 |
2008.09.29 |
申请人 |
CYCLACEL LIMITED |
发明人 |
HOLLICK, JONATHAN JAMES;JONES, STUART DONALD;FLYNN, CLAIRE JUNE;THOMAS, MICHEAL GEORGE |
分类号 |
C07D487/04;A61K31/551;A61P35/00;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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