THREE-DIMENSIONAL STRUCTURES OF HDAC9 AND CABIN1 AND COMPOUND STRUCTURES AND METHODS RELATED THERETO

摘要

Disclosed are the three-dimensional structures of two complexes: a Cabin 1/MEF2B/DNA complex and a MITR/MEF2B/DNA complex. Also disclosed are methods of using such structures and models derived therefrom in structure-based design methods to identify regulators of the interaction of MEF2 with its cognate ligands/corepressors, to compounds that can be designed or identified based on the knowledge of such structures and models, and to methods of using such compounds in therapeutic methods.