POLYMERIC CONJUGATES FOR TISSUE ACTIVATED DRUG DELIVERY
摘要
The present invention relates to a polymeric drug conjugate with one or more biologically active agents conjugated via an enzymatically cleavable linker to either a regular repeating linear unit comprising a water soluble polymer segment and a multifunctional chemical moiety, or a branched polymer comprising two or more water soluble polymer segments each bound to a common multifunctional chemical moiety, as well as to methods of making such conjugates. The present invention is also directed to pharmaceutical compositions comprising such conjugates and to the use of such conjugates to treat pathological conditions.
申请公布号
WO2004110358(A3)
申请公布日期
2009.04.02
申请号
WO2004US15513
申请日期
2004.05.17
申请人
VECTRAMED, INC.;BELINKA, BENJAMIN, A., JR.;PACHENCE, JAMES, M.;ROSA, JOSE, G.;SIMON, PAUL, M.
发明人
BELINKA, BENJAMIN, A., JR.;PACHENCE, JAMES, M.;ROSA, JOSE, G.;SIMON, PAUL, M.