发明名称 |
N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
摘要 |
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives. |
申请公布号 |
AU2008304200(A1) |
申请公布日期 |
2009.04.02 |
申请号 |
AU20080304200 |
申请日期 |
2008.09.26 |
申请人 |
JOHNS HOPKINS UNIVERSITY;CARDIOXYL PHARMACEUTICALS, INC. |
发明人 |
ANDREW D. COHEN;FREDERICK ARTHUR BROOKFIELD;JOHN P. TOSCANO;VINCENT JACOB KALISH;LISA MARIE FROST;STEPHEN MARTIN COURTNEY |
分类号 |
C07C311/48;A61K31/18;A61K31/192;A61K31/235;A61K31/5377;A61P9/04;A61P9/10;C07D295/192;C07D333/34;C07D333/38 |
主分类号 |
C07C311/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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