RENOPROTECTION BY GROWTH HORMONE-RELEASING HORMONE AND AGONISTS

摘要

In the present study, regulation of renal and pituitary GHRH-R mRNA levels w as examined using in vivo models of NaCl or water homeostasis disruption. The presence of a unique GHRH/GHRH-R system in Henle's loop ascending thin limb cell and the specific regulation of GHRH-R mRNA levels and GHRH sensitivity in a situation of hyperosmotic stress, together with the strong effect of GHRH on mitochondrial and nuclear DNA repair/synthesis, indicate a role for GHRH in renoprotection. GHRH appears to be involved in adaptive processes related to DNA repair and/or synthesis thereby protecting ascending limb cell function in subjects with renal vulnerability (aging, diabetes) and were a health event could lea d to a production of oxidative stress (antibiotic toxicity, cancer chemotherapeutic agent toxicity, infection, inflammation, ischemia ) and renal failure.