Methods for preventing reactivation of latent virus and controlling virus replication

摘要

Use of a composition capable of binding to a cell membrane-expressed CD40, wherein the binding of the composition to the CD40 on the surface of the cell generates a stimulatory signal to the cell for the preparation of a pharmaceutical composition for preventing latend <Italic>Alphaherpesvirinae</Italic> virus or <Italic>Betaherpesvirinae</Italic> virus reactivation or controlling latent <Italic>Alphaherpesvirinae</Italic> virus or <Italic>Betaherpesvirinae</Italic> virus replication, wherein the composition comprises: (a) an agonist antibody that specifically binds to a cell-expressed CD40, or a composition comprising a subsequence of an anti-CD40 agonist antibody, wherein the subsequence comprises an antigen binding site that specifically binds to a cell surface CD40; or (b) a soluble CD40-ligand polypeptide that specifically binds to a cell-expressed CD40, or a composition comprising a subsequence of a CD40-ligand polypeptide, wherein the subsequence comprises a CD40 binding site that specifically binds to a cell surface CD40.