| 发明名称 |
Reverse hydroxamic acid derivatives |
| 摘要 |
Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Ar1 is an arylene or the like; Ar2 is an optionally substituted aryl, a heteroaryl or the like; R1 is a hydrogen atom, an alkyl or the like; R2a is a substituted cycloaryl, a heterocycloaryl or the like) and a general formula (I): (wherein A, Ar1, Ar2, and R1 are the same as defined above and R2 is an hydrogen atom, R2a or the like) and salts thereof, which have TNF-alpha converting enzyme (TACE) inhibitory activity.
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| 申请公布号 |
US7511144(B2) |
申请公布日期 |
2009.03.31 |
| 申请号 |
US20040488530 |
申请日期 |
2004.03.04 |
| 申请人 |
KAKEN PHARMACEUTICAL CO., LTD. |
发明人 |
SHIMANO MASANAO;KAMEI NORIYUKI;TANAKA TOMOHIRO;HARADA TATSUHIRO;HAINO MAKOTO;OKUYAMA AKIHIKO;ARAKAWA YOSHIO;MURAKAMI YOSHIKO |
| 分类号 |
C07D215/38;A61K31/165;A61K31/357;A61K31/435;A61K31/47;A61K31/4709;A61K31/496;A61K31/55;A61P1/14;A61P1/16;A61P3/10;A61P7/06;A61P9/00;A61P9/10;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P19/02;A61P19/08;A61P21/00;A61P29/00;A61P31/00;A61P35/00;A61P37/00;A61P37/08;A61P43/00;C07C317/28;C07D207/20;C07D211/70;C07D213/30;C07D213/42;C07D215/14;C07D215/44;C07D277/14;C07D317/72;C07D319/06;C07D401/12;C07D405/12;C07D409/12;C07D417/12;C07D491/10;C07D491/113 |
主分类号 |
C07D215/38 |
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