use of CRTH2 antagonist compounds in therapy

摘要

Disclosed are 5-halo-indol-1-yl acetic acid derivatives of formulae I and II, wherein the substituents are as defined in the specification. The compounds useful for the treatment or prevention of diseases and conditions mediated by PGD2 at the CRTH2 receptor, such as allergic asthma, perennial allergic rhinitis, seasonal allergic rhinitis, atopic dermatitis, contact hypersensitivity (including contact dermatitis), conjunctivitis, especially allergic conjunctivitis, eosinophilic bronchitis, food allergies, eosinophilic gastroenteritis, inflammatory bowel disease, ulcerative colitis and Crohn's disease, mastocytosis, autoimmune diseases such as hyper IgE syndrome and systemic lupus erythematus, psoriasis, acne, multiple sclerosis, allograft rejection, reperfusion injury, chronic obstructive pulmonary disease, rheumatoid arthritis, psoriatic arthritis and osteoarthritis.