发明名称 |
Process for the preparation of tubulin inhibitors |
摘要 |
Disclosed is a process for the preparation of 6-[(substituted) phenyl]-triazolopyrimidine dicarboxylic acid salt and as a hydrated salt having the structural formula (I) wherein: R1 is CF3 or C2F5; R2 is H or C1-C3 alkyl; n is an integer of 2, 3, or 4; X is Cl or Br; R3 and R4 are each independently H or C,-C3 alkyl; or R3 and R4 when optionally taken together with the nitrogen atom to which each is attached form a 4 to 6 membered saturated heterocyclic ring having 1-2 nitrogen atoms and 0-1 oxygen atoms or 0-1 sulphur atoms, and optionally substituted with R5; R5 is C,-C3 alkyl; wherein the dotted line is an optional bond.
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申请公布号 |
NZ547471(A) |
申请公布日期 |
2009.03.31 |
申请号 |
NZ20040547471 |
申请日期 |
2004.12.07 |
申请人 |
WYETH |
发明人 |
WU, YANZHONG;SCHMID, JEAN;AFRAGOLA, JAY THOMAS;BLUM, DAVID MICHAEL;AYRAL-KALOUSTIAN, SEMIRAMIS |
分类号 |
C07D487/04;(IPC1-7):C07D487/04 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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