Electrotransport system and method for transdermal delivery of an anticoagulant

摘要

Disclosed is device for transdermally delivering an anticoagulant agent by electrotransport, comprising: a donor reservoir comprising a source of the anticoagulant agent; a counter reservoir; a source of electrical power electrically connected to the reservoirs; and a control circuit that applies current of a constant density, wherein operation of the device maintains a therapeutically desired plasma concentration of the anticoagulant agent. Preferably, the anticoagulant comprises a benzamidine or a naphthamidine derivative. A particularly preferred benzamidine derivative is a 2-[3-[4-(4-piperidinyloxy) anilino]-1-propenyl]benzamidine derivative. The devices are configured to maintain a plasma concentration of 20-80 ng/mL or providing a flux in the range of approximately 20 - 40 mg/day. Suitable current densities include 0.050 and 0.10 mA/cm2. The devices are also configured to deliver the anticoagulants to precisely maintain the desired plasma concentrations. The disclosure also relates to treating thromboembolic disease and inhibiting Factor Xa.