Pyrazoles and methods of making and using the same

摘要

Pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein the variables are as defined in the specification. These compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, and particularly useful as for inhibiting metastasis of tumor cells, for treating a disease or disorder mediated by an overexpression of TGFbeta and for treating fibrotic disorders.