摘要 |
<p>Disclosed is a compound represented by the formula (1) or a salt thereof, which has excellent inhibitory activity on the production of prostaglandin E2 and is useful as an active ingredient for a pharmaceutical agent having reduced adverse side effects including gastrointestinal disorders [in the formula, <u>----</u> represents a single bond or a double bond; R<sup>1</sup> represents a hydrogen atom or an alkyl group; R<sup>2</sup> and R<sup>3</sup> independently represent a hydrogen atom or an alkyl group; R<sup>4</sup> and R<sup>5</sup> independently represent a hydrogen atom, a hydroxy group, an alkoxy group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R<sup>6</sup> represents a hydrogen atom, a cyano group, an alkoxycarbonyl group, or a carboxy group; R<sup>7</sup> represents one or two substituents on the benzene ring (each of the substituents represents a hydrogen atom, a halogen atom, a nitro group, a cyano group, a hydroxy group, an amino group, an alkyl group, or an alkoxy group); A represents a non-aromatic 5- or 6-membered heterocyclic ring containing one sulfur atom or two contiguous sulfur atoms (which may independently be an oxide); W<u>----</u> represents an oxo group, a hydrogen atom, an alkyl group, a hydroxy group, an alkoxy group, or a halogen atom; and X represents an oxygen atom or a sulfur atom.</p> |