发明名称 |
АНТИ-CD30 АНТИТЕЛО, ХОЗЯЙСКАЯ КЛЕТКА, СПОСОБ ИНГИБИРОВАНИЯ РОСТА КЛЕТОК, ЭКСПРЕССИРУЮЩИХ CD30, И СПОСОБ ИНГИБИРОВАНИЯ РОСТА ОПУХОЛЕВЫХ КЛЕТОК, ЭКСПРЕССИРУЮЩИХ CD30 |
摘要 |
The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided. |
申请公布号 |
RU2007134661(A) |
申请公布日期 |
2009.03.27 |
申请号 |
RU20070134661 |
申请日期 |
2006.02.17 |
申请人 |
МЕДАРЕКС, ИНК. (US) |
发明人 |
БЛЭК Амели Нэнси (US);КАРДАРЕЛЛИ Джозефин М. (US) |
分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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