发明名称 |
ATM-Dependent Phosphorylation of Sp1 Is Involved in the Cellular Response to DNA Damage and Enhances Cellular Survival After DNA Damage |
摘要 |
The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO.: 2) at serine residue 101 (known herein as phosphoserine101 Sp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated with increased cellular viability in response to DNA damage.
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申请公布号 |
US2009081712(A1) |
申请公布日期 |
2009.03.26 |
申请号 |
US20080187187 |
申请日期 |
2008.08.06 |
申请人 |
D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE |
发明人 |
CLIFFORD JANE |
分类号 |
G01N33/53;C07K16/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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