发明名称 |
SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT |
摘要 |
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
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申请公布号 |
US2009081293(A1) |
申请公布日期 |
2009.03.26 |
申请号 |
US20070946028 |
申请日期 |
2007.11.27 |
申请人 |
MURASE KATSUYUKI;WAN JINPING;STANKUS JOHN;DAVALIAN DARIUSH;LUDWIG FLORIAN |
发明人 |
MURASE KATSUYUKI;WAN JINPING;STANKUS JOHN;DAVALIAN DARIUSH;LUDWIG FLORIAN |
分类号 |
A61K9/10;A61K9/14;A61K31/661;A61K38/10;A61K38/17;A61P3/00 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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