POLYMER CONJUGATE OF COMBRETASTATIN

摘要

A novel derivative of a combretastatin which has water solubility and is capable of releasing a drug independent of biological enzymes in which individual differences are likely caused and whose effective therapeutic effect can be expected has been demanded.A polymer conjugate of a combretastatin, characterized by having a structure in which a hydroxy group of a combretastatin is linked via an ester bond to a carboxylic acid group of the following polymer moiety in a block copolymer of a polyethylene glycol structure moiety with a polymer moiety having two of more carboxylic acid groups such as polyaspartic acid or polyglutamic acid is provided.