发明名称 |
METHOD FOR ISOLATING HEPATITIS C VIRUS PEPTIDES |
摘要 |
Described are methods for isolating Hepatitis C Virus peptides (HPs) that have a binding capacity to a MHC/HLA molecule or a complex comprising the HCV-peptide and the MHC/HLA molecule. In one aspect, these methods include providing a pool of HCV-peptide, said pool containing HCV-peptides which bind to said MHC/HLA molecule and HCV-peptides which do not bind to said MHC/HLA molecule, contacting said MHC/HLA molecule with said pool of HCV-peptides whereby a HCV-peptide which has a binding capacity to said MHC/HLA molecule binds to said MHC/HLA molecule and a complex comprising said HCV-peptide and said MHC/HLA molecule is formed, detecting and optionally separating said complex from the HCV-peptide which do not bind to said MHC/HLA molecule and optionally isolating and characterizing the HCV-peptide from said complex. Also described are immunogenic compositions that stimulate a specific T cell response to hepatitis C virus when administered to a subject in an effective amount.
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申请公布号 |
US2009081246(A1) |
申请公布日期 |
2009.03.26 |
申请号 |
US20080112758 |
申请日期 |
2008.04.30 |
申请人 |
BUSCHLE MICHAEL;HABEL ANDRE;KLADE CHRISTOPH;MATTNER FRANK;OTAVA OLEKSANDR;VYTVYTSKA ORESTA;ZAUNER WOLFGANG;ZINKE SANDRA;KIRLAPPOS HELEN |
发明人 |
BUSCHLE MICHAEL;HABEL ANDRE;KLADE CHRISTOPH;MATTNER FRANK;OTAVA OLEKSANDR;VYTVYTSKA ORESTA;ZAUNER WOLFGANG;ZINKE SANDRA;KIRLAPPOS HELEN |
分类号 |
A61K39/00;A61K35/12;A61K38/00;A61K39/12;A61K39/145;A61K39/29;C07K7/06;C07K7/08;C07K14/005;C07K14/045;C07K14/11;C07K14/18;C12N5/00;G01N33/576 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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