| 发明名称 |
USE AND TARGETING OF CD98 LIGHT-CHAIN PROTEINS IN THERAPIES FOR THYROID HORMONE DISORDERS |
| 摘要 |
The invention is related to the normalization of thyroid hormone transport by modulation of 4F2hc, CD981c, and the 4F2hc-CD981c heterodimer. Approaches to identify compounds that modulate thyroid hormone disorders, methods of identifying agonists and antagonists that modulate thyroid hormone disorders, and methods of making pharmaceuticals that ameliorate a thyroid hormone disorder are described herein.
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| 申请公布号 |
US2009081212(A1) |
申请公布日期 |
2009.03.26 |
| 申请号 |
US20080182030 |
申请日期 |
2008.07.29 |
| 申请人 |
THE GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH |
发明人 |
SHI YUN-BO;TAYLOR PETER M.;PETER GEORGE J.;RITCHIE JAMES W.A. |
| 分类号 |
A61K39/395;G01N33/78 |
主分类号 |
A61K39/395 |
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