摘要 |
The crude extract of Plectranthus Amboinicus (PA) has anti-inflammatory effects and can inhibit AP-1 binding in vitro. The incubation with PA crude extract resulted in significant inhibition of the LPS-induced expression of IL-6, IL-12, MCP- 1, and RANTES in HUVEC cells. After the crude extract was further fractionated using preparative HPLC, fraction 8, 9, 10 and 11 were identified to inhibit the AP-1 binding activity. The active component of fraction 8 is Mena 987; fraction 9 is Mena 998; fraction 10 is Mena 9102; and fraction 11 is rosmarinic acid and the synthestic rosmarinic acid analogues. Other compounds showed inhibitory activities as well. These compounds have inhibitory effects on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression or activities of AP-1 are involved. |
申请人 |
WONG, CHI-HUEY;CHENG, YIH-SHYUN, E.;YU, HUI-MING;CHENG, TING-JEN, R.;LIN, KUN-HSIEN;HUNG, JUNG-TUNG |
发明人 |
WONG, CHI-HUEY;CHENG, YIH-SHYUN, E.;YU, HUI-MING;CHENG, TING-JEN, R.;LIN, KUN-HSIEN;HUNG, JUNG-TUNG |