PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CATARACT

摘要

The present invention relates to a pharmaceutical composition for preventing or treating cataract comprising (a) a therapeutically effective amount of a transglutaminase 2 (TGase2) inhibitor or N-acetylcysteine (NAC); and (b) a pharmaceutically acceptable carrier, and a method for screening a substance to prevent or treat cataract. The present invention definitely demonstrates molecular mechanism underlying cataractogenesis and provides a novel molecular target of cataract therapeutics. Moreover, the cataract therapeutics of this invention effectively prevent or treat cataract with much higher safety.