| 发明名称 |
THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGEN |
| 摘要 |
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility complex (MHC). The invention provides a method of activating a signaling pathway and/or killing a cancer cell using a receptor that is similar to or is a T cell receptor
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| 申请公布号 |
US2009081172(A1) |
申请公布日期 |
2009.03.26 |
| 申请号 |
US20080258545 |
申请日期 |
2008.10.27 |
| 申请人 |
UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
FINN OLIVERA J.;ALAJEZ NEHAD M.;SCHMIELAU JAN;ALTER MARK D. |
| 分类号 |
A61K35/12;A61K31/7088;A61P31/00;C07K14/00;C12N5/06;C12N15/00;C12N15/11;C12N15/87;G01N1/30 |
主分类号 |
A61K35/12 |
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