INHIBITOR OF THE MET-RECEPTOR AND ITS USE

摘要

The present invention relates to polypeptides being part of the Met-receptor forming a binding pocket allowing binding of inhibitors of the Met-receptor. In particular, the present invention relates to isolated and purified polypeptides consisting of a portion of the Met-receptor. In a further aspect, the present invention relates to the use of said polypeptide as a screening tool for an agent for treating or preventing cancer. Another aspect of the present invention relates to a method for identifying potential Met-receptor inhibitors based on the three-dimensional structure of the newly identified binding pocket for specific binding of inhibitors of the Met-receptor. Another aspect relates to the crystalline form of the Met-receptor molecule and its use for identifying potential inhibitor of the said receptor as well as inhibitor itself.